DSpace Community: Assistant Professor, Chaltlang Lily Veng, Aizawl

The therapeutic potential of Houttuynia cordata: A current review☆

Sat, 01 Jan 2022 00:00:00 GMT

Title: The therapeutic potential of Houttuynia cordata: A current review☆ Authors: Laldinsangi Abstract: The search and development of new drugs for the treatment of numerous illnesses afflicting humans of all ages is an unending endeavour. Moreover, there is constant demand to identify more compounds exhibiting pharmacological properties with improved efficacy and minimal side effects compared to the existing ones. Plants have always served as rich sources of pharmaceuticals, and offer better advantages than synthetic compounds in terms of diversity, production scale and safety. Houttuynia cordata is a traditional medicinal plant that is widely distributed in East Asia. Apart from its consumption as a delicacy in many countries, it has a rich history of medicinal use and numerous studies have reported its pharmacological activity against inflammation, cancer, viruses, bacteria, hyperglycaemia, obesity, etc. The various phytoconstituents that have been isolated from this plant include flavonoids, phenolic acids, volatile/essential oils and alkaloids whose therapeutic potentials are yet to be fully harnessed. This review provides an updated summary of the biological activity and therapeutic potential of H. cordata, its phytocompounds and derivatives. The amalgamation of traditional plant-derived medicines with modern scientific methods can provide better insights to their mechanism of action and also contribute greatly to the discovery and synthesis of new pharmaceuticals.

Tobacco consumption and its relation to time taken to death among COVID-19 patients died in an intensive care unit. A retrospective and descriptive study from Mizoram, India Lalnun Diki1,

Wed, 01 Nov 2023 00:00:00 GMT

Title: Tobacco consumption and its relation to time taken to death among COVID-19 patients died in an intensive care unit. A retrospective and descriptive study from Mizoram, India Lalnun Diki1, Authors: Laldinsangi Abstract: The relationship between tobacco consumption and coronavirus disease 2019 (COVID-19) deaths among patients admitted in an intensive care unit (ICU) has not been studied in North-east parts of India. Aims and Objectives: The aims and objectives of the present study were to study the prevalence of smoke form and smokeless form of tobacco usage among the patients who had died of COVID-19 and to study the relationship of tobacco usage and number of duration of stay in ICU and number of days taken to death from the time of testing positive. Materials and Methods: This was a retrospective descriptive study of 279 COVID-19-positive patients who got admitted in ICU in Zoram Medical College. Mizoram from February 2020 to February 2022 and subsequently died because of COVID-19 in ICU. The data regarding age, sex, date of testing positive, date of admission in ICU, and date of death were collected from the patient case sheet. The details regarding tobacco consumption were collected from the patients close relatives. Descriptive analysis was carried out by mean and standard deviation along with range for quantitative variables, frequency, and proportion for categorical variables. Data were analyzed using IBM software version 22. P<0.05 was considered as significant. Results: The mean age of the study population was 63.8 years. Majority were males 178 (63.80%). 198 (70.97%) had comorbidities. One hundred and twenty-nine (46.24%) were tobacco users. Mean stay in ICU in days was 7.75 days. Majority were using smokeless form of tobacco 73 (56.59%). The mean duration of survival in days from time tested positive to the death was 39.52 days among tobacco users when compared with non-tobacco users (47.48 days) (P=0.265). Mean duration of survival was 53.07 days among smoke form versus 31.3 days among smokeless form users. (P=0.031). Conclusion: There is no conclusive finding to say that there is a significant difference in time taken to death between tobacco users and non-tobacco users

Identification, cloning and expression profile of sycp3 during gonadal cycle and after siRNA silencing in catfish

Mon, 01 Jan 2018 00:00:00 GMT

Title: Identification, cloning and expression profile of sycp3 during gonadal cycle and after siRNA silencing in catfish Authors: Laldinsangi Abstract: Molecular mechanisms underlying germ cell development, proliferation and maturation in teleosts revealed the importance of transcription factors through functional genomic approaches which is often comparable to mammals. In the present study, a proteomic approach was employed to find novel molecules with reference to germ cell development in teleosts. Based on this, current work utilized two-dimensional (2D) gel electrophoresis combined with matrix assisted laser desorption/ionization time-of-flight (MALDI-TOF/TOF) mass spectrometry in an attempt to identify and compare the proteins which are expressed differentially in the male gonads of catfish during juvenile and adult stages. The 2D gel analysis identified the Sycp3 protein which was found to be up regulated in juvenile testis when compared to adult stages, and then the full length cDNA was cloned using the peptide sequence data from catfish testis. The spatio-temporal expression pattern of sycp3 was explored during the critical time period of gonadal development as well as at different phases of recrudescence in catfish using real-time PCR, followed by localization analysis by in situ hybridization and immunohistochemistry. In addition, in vivo transient knockdown using PEI mediated sycp3-esiRNA in adult catfish during recrudescence showed a decrease in sycp3 expression, which also affected the expression level of various testis-related genes. Present findings suggest that Sycp3 might have a potential role in the development and maintenance of testicular function in catfish

Two-dimensional proteomic analysis of gonads ofair-breathing catfish, Clarias batrachus after theexposure of endosulfan and malathionC

Wed, 01 Jan 2014 00:00:00 GMT

Title: Two-dimensional proteomic analysis of gonads ofair-breathing catfish, Clarias batrachus after theexposure of endosulfan and malathionC Authors: Laldinsangi Abstract: tEndocrine disrupting chemicals have raised public concern, since their effects have beenfound to interfere with the physiological systems of various organisms, especially dur-ing critical stage of development and reproduction. Endosulfan and malathion, pesticideswidely used for agricultural purposes, have been known to disrupt physiological functions inaquatic organisms. The current work analyzes the effects of endosulfan (2.5 parts per billion[ppb]) and malathion (10 ppb) on the reproductive physiology of catfish (Clarias batrachus) byevaluating protein expression profiles after 21 days of exposure. The proteomic profile oftestis and ovary after exposure to endosulfan showed downregulation of proteins such asubiquitin and Esco2, and upregulation in melanocortin-receptor-2 respectively. Malathionexposed ovary showed upregulated prolactin levels. Identification of proteins differentiallyexpressed in gonads due to the exposure to these pesticides may serve as crucial indicationsto denote their disruptive effects at the level of proteins