http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/167 Assistant Professor, Hlimen, Aizawl Wed, 29 Apr 2026 10:25:34 GMT 2026-04-29T10:25:34Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/387 Title: Saccharomyces and Their Potential Applications in Food and Food Processing Industries Authors: Singh, Garima Abstract: Genus Saccharomyces is one of the most explored yeast species, especially in the food processing and allied food industries. Among them S. cerevisiae, S. boulardii, and S. cerevisiae var. boulardii are the leading yeasts that find relatively major functional usages as natural fermenters in various food applications. As humanity as a whole is on the search for an easy cure into healthy living among their busy schedule, healthy gut, balanced diet, probiotics, and functional/fortified foods have gained immense importance. Yeast and Saccharomyces could play a substantial role in ensuring that such diet balances are maintained by utilizing their natural abilities to ferment food items according to their needs. In this context, this book chapter attempts to survey an overhaul of Saccharomyces in the current food market, food industry, and food technology and their role in food processing industries. Sat, 19 Jun 2021 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/387 2021-06-19T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/386 Title: Traditionally Used Medicinal Plants Belongs to Family Asteraceae for the Treatment of Cancer in Mizoram, Northeast India Authors: Singh, Garima Abstract: The traditional knowledge and use of medicinal plant species from the plant family Asteraceae was reviewed for the treatment of several types of cancers in Aizawl District, Mizoram, Northeast India. Traditional healers and patients suffering from various cancers in the study area were interviewed with the help of local translators to congregate the information for the use of medicinal plants against several prevalent cancers in this part of India. In the present review, we reported 22 plant species which were commonly used for the treatment of various cancers and ulcer. The most common used plant for the treatment of various cancers is Mikania micrantha followed by Ageratum conizoids. Leaves are the most common part used. The present review outlined the traditional information along with the major phytochemical compounds obtained from the listed plants which may be responsible for their traditional values in the selected study area. We hypothesized that the information could improve the traditional anti-cancer recipes and might contribute to a better national or international health system in future Fri, 01 Sep 2017 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/386 2017-09-01T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/383 Title: HMG-CoA reductase inhibition medicated hypocholesterolemic and antiatherosclerotic potential of phytoconstituents of an aqueous pod extract of Prosopis cineraria (L.) Druce: In silico, in vitro, and in vivo studies Authors: Singh, Garima Abstract: Hydrophilic bioactive compounds are copiously exhibited in aqueous extracts owed to solubility. The study was assigned to assess the ability of phytoconstituents of aqueous pod extract of Prosopis cineraria to inhibit 3-hydroxy-3-methylglutary-coenzyme A (HMG-CoA) reductase activity and regression in atherosclerotic plaque through in vitro, in vivo, and in silico assessments along with phytochemistry of extract. The test extract exhibited 17 leading compounds as examined by Liquid Chromatograph Triple Quadrupole Mass Spectroscope. In vitro assay of test extract showed 78.1% inhibition of HMG-CoA inhibition (IC50 was 0.03 μg/ml). In vivo assessments, hypercholesterolemia was induced by supplementing cholesterol powder and a high-fat diet. The treatment of test extract caused significant (p ≤ 0.001) improvements in the lipid profile and antioxidant levels. Subsequently, the reductions in the atherosclerotic plaque and improved lumen volume were pointedly observed. In silico analyses of molecular docking revealed potent interaction capabilities of cloprostenol with the target protein of HMGR. The interactions were validated through structural simulations of the molecular dynamics such as root mean square fluctuation, the radius of gyration, and solvent accessible surface area. The druggability of potent compounds was also examined. The results revealed that phytoconstituents of the test extract could inhibit HMGR and regress atherosclerotic plaque. Sat, 29 Oct 2022 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/383 2022-10-29T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/382 Title: DPP-4 inhibition mediated antidiabetic potential of phytoconstituents of an aqueous fruit extract of Withania coagulans (Stocks) Dunal: in-silico, in-vitro and in-vivo assessments Authors: Singh, Garima Abstract: The DPP-4 inhibition is an interesting target for the development of antidiabetic agents which promotes the longevity of GPL-1(Glucagon-like peptide 1). The current study was intended to assess DPP-4(Dipeptidyl Peptidase-4) inhibition mediated antidiabetic effect of phytocompounds of an aqueous fruit extract of Withania coagulans (Stocks) Dunal by in-vitro, in-silico and in-vivo approaches. The phytoconstituents screening was executed by LCMS (Liquid Chromatography with tandem mass spectrometry). The in-vitro and in-vivo, DPP-4 assays were performed by using available kits. The in-vitro DPP-4 activity was inhibited up to 68.3% by the test extract. Accordingly, in-silico determinations of molecular docking, molecular dynamics and pharmacokinetics were performed between the target enzyme DPP-4 and leading phytocompounds. The molecular dynamics authenticated the molecular docking data by crucial parameters of cytosolic milieu by the potential energy, RSMD (Root Mean Square Deviation), RSMF (Root Mean Square Fluctuation), system density, NVT (Number of particles at fixed volume, ensemble) and NPT (Number of particles at fixed pressure, ensemble). Accordingly, ADMET predictions assessed the druggability profile. Subsequently, the course of the test extract and the sitagliptin (positive control), instigated significant (p ≤ 0.001) ameliorations in HOMA indices and the equal of antioxidants in nicotinamide-streptozotocin induced type 2 diabetic animal model. Compassionately, the histopathology represented increased pancreatic cellular mass which caused in restoration of histoarchitectures. It has been concluded that phytoconstituents in W. coagulans aqueous fruit extract can regulate DPP-4, resulting in improved glucose homeostasis and enhanced endocrinal pancreatic cellular mass. Fri, 05 Aug 2022 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/382 2022-08-05T00:00:00Z