http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/157 Assistant Professor, PUC Campus Wed, 29 Apr 2026 13:24:12 GMT 2026-04-29T13:24:12Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/649 Title: Silk-based biomaterials have gained significant importance making them a promising choice for the future of medical technology due to their versatility and biocompatibility. They can be fabricated and tailored through various processing methods such as electrospinning, freeze-drying, and 3D printing, to achieve specific properties and structures namely sponges, hydrogels, films, and scaffolds that can be utilized for different biomedical applications. Biocompatibility, a unique property of silk-based biomaterials, has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of medicine. In this review, we have elaborately discussed different types of silk, their structural composition, and biophysical properties. Also, the current review focuses on highlighting various biomedical applications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin, eyes, teeth, bone, heart, nerves, and liver. Furthermore, we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors, food coating and packaging, textiles, drug delivery, and cosmetics. However, the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications Authors: Babu, Punuri Jayasekhar Abstract: Silk-based biomaterials have gained significant importance making them a promising choice for the future of medical technology due to their versatility and biocompatibility. They can be fabricated and tailored through various processing methods such as electrospinning, freeze-drying, and 3D printing, to achieve specific properties and structures namely sponges, hydrogels, films, and scaffolds that can be utilized for different biomedical applications. Biocompatibility, a unique property of silk-based biomaterials, has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of medicine. In this review, we have elaborately discussed different types of silk, their structural composition, and biophysical properties. Also, the current review focuses on highlighting various biomedical applications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin, eyes, teeth, bone, heart, nerves, and liver. Furthermore, we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors, food coating and packaging, textiles, drug delivery, and cosmetics. However, the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications Mon, 01 Jan 2018 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/649 2018-01-01T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/648 Title: Applications of silk-based biomaterials in biomedicine and biotechnology Authors: Babu, Punuri Jayasekhar Abstract: Silk-based biomaterials have gained significant importance making them a promising choice for the future of medical technology due to their versatility and biocompatibility. They can be fabricated and tailored through various processing methods such as electrospinning, freeze-drying, and 3D printing, to achieve specific properties and structures namely sponges, hydrogels, films, and scaffolds that can be utilized for different biomedical applications. Biocompatibility, a unique property of silk-based biomaterials, has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of medicine. In this review, we have elaborately discussed different types of silk, their structural composition, and biophysical properties. Also, the current review focuses on highlighting various biomedical applications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin, eyes, teeth, bone, heart, nerves, and liver. Furthermore, we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors, food coating and packaging, textiles, drug delivery, and cosmetics. However, the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications Fri, 01 Mar 2024 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/648 2024-03-01T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/647 Title: Piper betle-mediated green synthesis of biocompatible gold nanoparticles Authors: Babu, Punuri Jayasekhar Abstract: Here, we report the novel use of the ethonolic leaf extract of Piper betle for gold nanoparticle (AuNP) synthesis. The successful formation of AuNPs was confirmed by UV-visible spectroscopy, and different parameters such as leaf extract concentration (2%), gold salt concentration (0.5 mM), and time (18 s) were optimized. The synthesized AuNPs were characterized with different biophysical techniques such as transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDX). TEM experiments showed that nanoparticles were of various shapes and sizes ranging from 10 to 35 nm. FTIR spectroscopy revealed that AuNPs were functionalized with biomolecules that have primary amine group –NH2, carbonyl group, –OH groups, and other stabilizing functional groups. EDX showed the presence of the elements on the surface of the AuNPs. FT-IR and EDX together confirmed the presence of biomolecules bounded on the AuNPs. Cytotoxicity of the AuNPs was tested on HeLa and MCF-7 cancer cell lines, and they were found to be nontoxic, indicating their biocompatibility. Thus, synthesized AuNPs have potential for use in various biomedical applications. Mon, 01 Jan 2018 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/647 2018-01-01T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/646 Title: Synthesis and characterization of citrate-capped gold nanoparticles and their application in selective detection of creatinine (A kidney biomarker) Authors: Babu, Punuri Jayasekhar Abstract: A simple, sensitive, and highly selective detection method was developed for creatinine using citrate-capped gold nanoparticles (C-AuNPs). TEM analysis confirmed the synthesis of the C-AuNPs and they were mostly spherical in shape. FTIR data showed peaks at 3302 cm􀀀 1, 1635 cm􀀀 1, 1219 cm􀀀 1 and 771 cm􀀀 1 indicating the presence of O–H, C=C, C–O, C–C groups on the surface of the synthesized C-AuNPs. XRD analysis revealed peaks at 33.8, 44.4, 64.6, 77.5, and 81.6◦ confirming the crystalline nature of the C-AuNPs. The principle of this method is based on the aggregation of C-AuNPs induced by the creatinine molecules which has been successfully employed for the colorimetric detection of creatinine ranging from 0.3 to 0.8 μg/100 μl (3–8 ppm). The degree of aggregation of C-AuNPs was found to have a linear relationship with the concentration of creatinine which allows the development of a colour gradient based on the varying creatinine concentrations. UV–Vis spectrophotometric analysis further confirmed the selectivity of the method among different analytes such as ascorbic acid, nicotinic acid, polyvinyl pyrrolidone, glucose, uric acid, and bovine serum albumin. It has also been successfully applied for the detection of creatinine in urine mimic samples with good recovery rates. Therefore, this method can be successfully employed for both qualitative and quantitative analysis of creatinine. Tue, 12 Sep 2023 00:00:00 GMT http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/646 2023-09-12T00:00:00Z