http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/965 2025-10-30T07:10:15Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/966 Title: Synthesis of D-Fructose-Based Bifunctional Primary Amine-Thiourea Organocatalysts and Their Applications in Asymmetric Reactions Authors: Lalhriatpuia, C Abstract: The preparation of a new class of six bifunctional thiourea organocatalysts having a Dfructose scaffold and a primary amino group was demonstrated. In the present study, the novel organocatalysts exhibited excellent enantio- and moderate diastereoselectivities in the asymmetric Michael addition of aliphatic ketones and 1,3-diketone to substituted nitroolefins at room temperature. In addition, the direct asymmetric aldol reaction between cyclic aliphatic ketone and aromatic aldehydes was also studied in the presence of the saccharide-thiourea organocatalysts giving excellent yield with moderate enantioselectivity. 2023-10-16T00:00:00Z