http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/563 2026-05-21T02:46:15Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1003 Title: Monofunctional primary amine: A new class of organocatalyst for asymmetric Aldol reaction Authors: Vanlaldinpuia, K Abstract: A new class of organocatalysts involving a primary amine as the only functional group is developed for catalytic asymmetric aldol reaction of cyclohexanone/cyclopentanone with various aryl aldehydes in the presence of benzoic acid as an additive at −10◦C. In an unexpected observation, the primary amine catalyzed reactions gave excellent yield and good to excellent stereoselectivity, while secondary amines were found to have little or no reactivity under similar reaction conditions. 2017-01-13T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/992 Title: Monofunctional primary amine: A new class of organocatalyst for asymmetric Aldol reaction Authors: Vanlaldinpuia, K Abstract: A new class of organocatalysts involving a primary amine as the only functional group is developed for catalytic asymmetric aldol reaction of cyclohexanone/cyclopentanone with various aryl aldehydes in the presence of benzoic acid as an additive at −10◦C. In an unexpected observation, the primary amine catalyzed reactions gave excellent yield and good to excellent stereoselectivity, while secondary amines were found to have little or no reactivity under similar reaction conditions. 2017-01-13T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/990 Title: Saccharide success: exploring the role of Dfructose-based thioureas as organocatalysts for the enantioselective Friedel–Crafts alkylation reaction† Authors: Vanlaldinpuia, K Abstract: In this study, a series of sixteen (16) D-fructose-based bifunctional thioureas were examined as organocatalysts for the enantioselective Friedel–Crafts alkylation of indoles and pyrrole with bnitrostyrenes. This investigation is a part of our ongoing project, which aims to expand the scope of application of D-fructose-based thioureas. Under the optimized low-temperature reaction conditions, the corresponding adducts were obtained with good yield (up to 95%) and excellent enantioselectivity (>99% ee). 2025-03-04T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/989 Title: Antioxidant and cytotoxic properties of Acmella oleracea Authors: Vanlaldinpuia, K Abstract: Acmella oleracea has been widely used in various traditional medicines for the treatment of different diseases ranging from infection, helminthiasis, peptic ulcer to dental abscess. In this experiment, we analysed the antioxidant property of the methanol extract of A. oleracea by hydroxyl radical-scavenging assay and hydrogen peroxide-scavenging assay. In both the scavenging assays, the plant extract showed free radical scavenging activities in a concentration-dependent manner. The cytotoxic property was also determined by MTT assay, which indicated a potential cytotoxic effect on cancer cell lines such as HeLa (ATCC® CCL-2TM) and V79 (ATCC® CCL-93TM) cells. Higher cytotoxicity was noticed on V79 with an IC50 of 54.341 µg/ml. The plant extract was only moderately toxic on HeLa. The results indicated that the plant contains important bioactive compounds having pharmacological properties. 2018-10-16T00:00:00Z