http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/181 Assistant Professor, Durtlang Leitan, Aizawl 2025-10-30T07:27:27Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1004 Title: Asymmetric Michael addition using sugar derived organocatalysts Authors: Vanlaldinpuia, K Abstract: Sugars are low-molecular-weight carbohydrates which consist of polyhydroxyl and carbonyl (aldehyde or ketone) functional groups. Different types of compounds derived from sugars have been used extensively as powerful and effective catalysts for asymmetric synthesis. They are readily available at a reasonable price, easily prepared, no metal contamination and are inert towards moisture and air. They are highly functionalized and have well defined stereogenic centres. Most of them are employed as chiral ligands in metal based asymmetric catalysis and are used for various asymmetric transformations. Different compounds derived from sugars have also been used recently as organocatalysts for asymmetric synthesis. The present article provides some of the organocatalysts used for asymmetric synthesis 2017-08-07T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1003 Title: Monofunctional primary amine: A new class of organocatalyst for asymmetric Aldol reaction Authors: Vanlaldinpuia, K Abstract: A new class of organocatalysts involving a primary amine as the only functional group is developed for catalytic asymmetric aldol reaction of cyclohexanone/cyclopentanone with various aryl aldehydes in the presence of benzoic acid as an additive at −10◦C. In an unexpected observation, the primary amine catalyzed reactions gave excellent yield and good to excellent stereoselectivity, while secondary amines were found to have little or no reactivity under similar reaction conditions. 2017-01-13T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1001 Title: An efficient oxidation method for conversion of alcohols to their corresponding carboxylic acids and ketones using oxone as co-oxidant Authors: Vanlaldinpuia, K Abstract: An efficient and practical method for the conversion of alcohols to their corresponding carboxylic acids and ketones via a ruthenium chloride-catalyzed oxidation process has been developed. The reaction proceeded under mild reaction condition using environmentally friendly oxone as a cooxidant. Various alcohols were examined to provide the desired products in good yields. 2014-11-30T00:00:00Z http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1000 Title: Chemical profiling of alkylamides from the "herbal Botox", Acmella oleracea, cultivated in Mizoram and their pharmacological potentials Authors: Vanlaldinpuia, K Abstract: Aim: Methodology: Results: Interpretation: Keywords: To perform chemical analysis and study the antibacterial and antiparasitic activities of Acmella oleracea extracts. The methanol, chloroform, and hexane extracts of A. oleraceawere prepared and analysed by GC-MS and HPLC. An active ethyl acetate fraction obtained from methanol extract was tested on Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and a Gram-positive species Bacillus subtilis. An intestinal tapeworm, Raillietina echinobothrida was used for anthelmintic study and the effects were examined by scanning electron microscopy. GC-MS revealed that N-isobutyl-(2E, 4Z, 8Z, 10E)- dodecatetraenamide was the dominant compound in all the three extracts. N-(2-Methylbutyl)dodeca-2,4-diene-8,10- diynamide, N-(2-phenylethyl) non-2(E)-en-6, 8-diynamide and (2E,4E,10E)-N-isobutylhexadeca-2,4,10-trienamide were also detected. (2E,6Z,8E)-N-Isobutyl-2,6,8- decatrienamide was confirmed by HPLC in all extracts. The methanol-ethyl acetate extract was effective against all the four bacteria with maximum activity against Bacillus subtilis. Anthelmintic effects on R. echinobothrida included tegumental shrinkage, surface erosion, obliteration of the spines, and formation of pits on the body segments. A. oleracea is shown to be rich in alkylamides. As the dominant compounds, these alkylamides can be attributed to the antibacterial and anthelmintic properties of the medicinal plant. 2020-07-07T00:00:00Z