http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/812 2026-05-02T22:36:34Z 2026-05-02T22:36:34Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1082 2025-10-21T07:04:04Z 2023-10-11T00:00:00Z

Title: Molecular modeling of lupeol for antiviral activity and cellular effects Authors: Lalruatfela, B Abstract: Lupeol is a naturally occurring pentacyclic triterpenoid present in several plants and is attributed to have anticancer, antiparasitic, and anti-inflammatory properties. Owing to its known antipathogenic and immunomodulatory activities, an in silico study was done on its potential interactions with various surface proteins of SARS-CoV-2, a coronavirus that causes COVID-19. Molecular docking indicated that it binds effectively with SARS-CoV-2 proteins that are vital to the life cycle, structural integrity, and virulence of the virus. It showed high binding affinities on the main protease, nucleocapsid phosphoprotein, papain-like protease, RNA-dependent RNA polymerase, and spike glycoprotein. It was also analyzed for its possible targets on various proteins critical to immune signaling pathways, as well as for its cellular absorption, distribution, excretion, metabolism, and toxicity. The findings suggest that lupeol is a potential drug candidate as an antiviral medication against coronavirus and for immune-related disorders.

2023-10-11T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/813 2024-06-18T08:57:15Z 2019-08-30T00:00:00Z

Title: valuation of the Cytotoxic Effect of Tuibur (Tobacco Brew) in Different Cultured Cell Lines valuation of the Cytotoxic Effect of Tuibur (Tobacco Brew) in Different Cultured Cell Lines Authors: Lalruatfela, B Abstract: The consumption of tobacco and tobacco products is directly correlated to many human ailments including cancer. Tuibur.the brewed tobacco, is one of the forms of smokeless tobacco [1], which is frequently used by the inhabitants of Northeast India including Mizoram. The greater use of tobacco and its related products has led to increased frequency of cancer in this region of India. Therefore, it was decided to study the cytotoxicity of two grades of commonly used tuibur in cultured human peripheral blood lymphocytes (HPBLs), HeLa, V79 and Dalton’s lymphoma ascites (DLA) cells along with nicotine by MTT assay.Treatment of HPBLs, HeLa, V79 and DLA cells for 24 h with two grades of commercial tuibur and nicotine led to a concentration dependent rise in their cytotoxicity by MTT assay. Our results indicate that constant consumption of tuibur has a deleterious effect on cultured human peripheral blood lymphocytes, HeLa, V79 and DLA cells.

2019-08-30T00:00:00Z