http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/802 2026-05-25T22:40:39Z 2026-05-25T22:40:39Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/814 2024-06-18T09:00:34Z 2015-05-10T00:00:00Z

Title: Association of tobacco use, betel consumption and gastric cancer in Mizoram Authors: Lalruatfela, B Abstract: Cancer is a disease that affects the livelihood of humankind for ages. Dietary habit and lifestyle have been attributed to the development of many forms of cancer including gastric cancer. The state of Mizoram located in the northeastern India has been recorded to be a cancer prone area. Most Mizo people indulge in the use of smoke and smokeless tobacco and betel chewing. A study in this high cancer incidence zone is necessary to determine the actual cause of the disease. In this study, we evaluate the influence of tobacco use and betel consumption on gastric cancer. We con-clude that individuals with a family history of cancer who consumed betel, smoke and smokeless tobacco have a higher risk of gastric cancer. We also found an association between increased risk of gastric cancer and consumption of betel or sahdah alone and betel with sahdah.

2015-05-10T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/811 2024-06-18T08:49:16Z 2023-06-12T00:00:00Z

Title: Immunomodulatory and Antiallergic Potentials of the Bioactive Compounds of Ginger Authors: Lalruatfela, B Abstract: Allergy is an ever-increasing immune disorder and is often fatal under certain circumstances. Lack of total curative medication prompts the search for various compounds as the lead molecules. Ginger, Zingiber officinale Roscoe, is a well-established medicinal plant in different traditional practices. Its use as antiallergic or anti-inflammatory agent has been vindicated but the underlying mechanism of action is yet unknown. Method: In this study, we analyzed the phytocompounds characterized from ginger for their binding affinities on cysteinyl leukotriene receptor 1 (CysLTR1) and histamine H1 receptor (H1R) by molecular docking. The molecular interactions were compared against known agonists and antagonists of the two receptors. Results: The data indicate that ginger compounds have high binding affinity for both LTR1 and H1R comparable to those of antiallergic medications. The highest binding affinities were recorded for gingerenone-A (-7.3 kcal/mol) and zingiberol (-7.2 kcal/mol) on LTR1; and gingerenone-A (-8.7 kcal/mol) and α-curcumene (-8.0 kcal/mol) on H1R. Conclusion: In addition to antiallergic activity, molecular predications on the probable biological activities of the ginger compounds show that they can have a variety of medicinal applications including immunomodulatory and anticancer activities.

2023-06-12T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/810 2024-06-18T08:46:11Z 2020-10-07T00:00:00Z

Title: Nematocidal effects of tobacco infusion (tuibur) against intestinal helminth parasites of chicken Authors: Lalruatfela, B Abstract: To study the effect of tobacco infusion, locally known as tuibur in Mizoram, as an antiparasitic agent. A traditionally prepared tobacco infusion was tested for its possible effects on the nematode parasite, Ascaridia galli. The tobacco infusion was prepared in an exponential increase of concentrations, viz. 12.5, 25 and 50% from the original solution. Live and sentient A. galli were collected from the intestines of freshly slaughtered chicken, Gallus gallus domesticus. They were maintained in culture plates that contained phosphatebuffered saline (PBS) in a biological incubator maintained at 37±1ºC. Both tobacco infusion and standard drug showed a dose-dependent efficacy against the nematodes. Scanning electron microscopy of tobacco infusion-treated nematodes showed extensive structural damage. The sensory amphid w a s r u p t u r e d , a n d t h e surrounding lips collapsed. The cuticle was distorted and shrunk all over the body as patchy rows of longitudinal corrugations. Our data shows evidence that tobacco infusion has anthelmintic activity on parasitic nematodes and may serve as a promising candidate for pharmaceutical development.

2020-10-07T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/807 2024-06-18T08:40:31Z 2016-09-10T00:00:00Z

Title: Etiology of lung cancer among the Mizo people Authors: Lalruatfela, B Abstract: According to the National Cancer Registry Programme, Mizoram has the highest cancer incidence among the states of India. Lung cancer has been found to be very common among the Mizos and its etiology has never been scientifically analyzed in this high cancer incidence population. A hospi-tal based case-control study was conducted during March, 2014 to February, 2016. The study in-volved 106 histologically confirmed lung cancer patients and 212 matched cancer-free subjects act-ing as controls, all with the same ethnic background, i.e. Mizo. Among the cases, the risk of lung cancer was significantly elevated among ex-smokers (OR, 4.69; 95% CI, 2.36-9.32), but not among current smokers. Higher risks were seen for zozial smokers (OR, 2.51; 95% CI, 1.28-4.92). The in-creased risk was apparent among subjects who had smoked for ≥40 years. Exposure to environ-mental smoke at home and workplace were significantly associated with an increased risk of lung cancer. Higher risk was also observed for previous diagnosis of asthma (OR, 4.62; 95% CI, 1.75-12.23). Lower consumption of alcohol related with decreased risk of lung cancer (OR, 0.87; 95% CI, 0.37-2.05). Tobacco smoking was found to be the primary factor for developing lung cancer. Certain occupations like the transport industry, farming, carpentry or automobile works were found to increase the risk of lung cancer. Prior affliction with tuberculosis might also have the potential to increase the risk. However, low and moderate consumption of alcohol leads to de-crease risk of lung cancer.

2016-09-10T00:00:00Z