Assistant Professor, ITI Veng, Aizawl http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/258 2025-10-30T07:01:17Z 2025-10-30T07:01:17Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/1082 2025-10-21T07:04:04Z 2023-10-11T00:00:00Z

Title: Molecular modeling of lupeol for antiviral activity and cellular effects Authors: Lalruatfela, B Abstract: Lupeol is a naturally occurring pentacyclic triterpenoid present in several plants and is attributed to have anticancer, antiparasitic, and anti-inflammatory properties. Owing to its known antipathogenic and immunomodulatory activities, an in silico study was done on its potential interactions with various surface proteins of SARS-CoV-2, a coronavirus that causes COVID-19. Molecular docking indicated that it binds effectively with SARS-CoV-2 proteins that are vital to the life cycle, structural integrity, and virulence of the virus. It showed high binding affinities on the main protease, nucleocapsid phosphoprotein, papain-like protease, RNA-dependent RNA polymerase, and spike glycoprotein. It was also analyzed for its possible targets on various proteins critical to immune signaling pathways, as well as for its cellular absorption, distribution, excretion, metabolism, and toxicity. The findings suggest that lupeol is a potential drug candidate as an antiviral medication against coronavirus and for immune-related disorders.

2023-10-11T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/814 2024-06-18T09:00:34Z 2015-05-10T00:00:00Z

Title: Association of tobacco use, betel consumption and gastric cancer in Mizoram Authors: Lalruatfela, B Abstract: Cancer is a disease that affects the livelihood of humankind for ages. Dietary habit and lifestyle have been attributed to the development of many forms of cancer including gastric cancer. The state of Mizoram located in the northeastern India has been recorded to be a cancer prone area. Most Mizo people indulge in the use of smoke and smokeless tobacco and betel chewing. A study in this high cancer incidence zone is necessary to determine the actual cause of the disease. In this study, we evaluate the influence of tobacco use and betel consumption on gastric cancer. We con-clude that individuals with a family history of cancer who consumed betel, smoke and smokeless tobacco have a higher risk of gastric cancer. We also found an association between increased risk of gastric cancer and consumption of betel or sahdah alone and betel with sahdah.

2015-05-10T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/813 2024-06-18T08:57:15Z 2019-08-30T00:00:00Z

Title: valuation of the Cytotoxic Effect of Tuibur (Tobacco Brew) in Different Cultured Cell Lines valuation of the Cytotoxic Effect of Tuibur (Tobacco Brew) in Different Cultured Cell Lines Authors: Lalruatfela, B Abstract: The consumption of tobacco and tobacco products is directly correlated to many human ailments including cancer. Tuibur.the brewed tobacco, is one of the forms of smokeless tobacco [1], which is frequently used by the inhabitants of Northeast India including Mizoram. The greater use of tobacco and its related products has led to increased frequency of cancer in this region of India. Therefore, it was decided to study the cytotoxicity of two grades of commonly used tuibur in cultured human peripheral blood lymphocytes (HPBLs), HeLa, V79 and Dalton’s lymphoma ascites (DLA) cells along with nicotine by MTT assay.Treatment of HPBLs, HeLa, V79 and DLA cells for 24 h with two grades of commercial tuibur and nicotine led to a concentration dependent rise in their cytotoxicity by MTT assay. Our results indicate that constant consumption of tuibur has a deleterious effect on cultured human peripheral blood lymphocytes, HeLa, V79 and DLA cells.

2019-08-30T00:00:00Z Lalruatfela, B http://pucir.inflibnet.ac.in:8080/jspui/handle/123456789/811 2024-06-18T08:49:16Z 2023-06-12T00:00:00Z

Title: Immunomodulatory and Antiallergic Potentials of the Bioactive Compounds of Ginger Authors: Lalruatfela, B Abstract: Allergy is an ever-increasing immune disorder and is often fatal under certain circumstances. Lack of total curative medication prompts the search for various compounds as the lead molecules. Ginger, Zingiber officinale Roscoe, is a well-established medicinal plant in different traditional practices. Its use as antiallergic or anti-inflammatory agent has been vindicated but the underlying mechanism of action is yet unknown. Method: In this study, we analyzed the phytocompounds characterized from ginger for their binding affinities on cysteinyl leukotriene receptor 1 (CysLTR1) and histamine H1 receptor (H1R) by molecular docking. The molecular interactions were compared against known agonists and antagonists of the two receptors. Results: The data indicate that ginger compounds have high binding affinity for both LTR1 and H1R comparable to those of antiallergic medications. The highest binding affinities were recorded for gingerenone-A (-7.3 kcal/mol) and zingiberol (-7.2 kcal/mol) on LTR1; and gingerenone-A (-8.7 kcal/mol) and α-curcumene (-8.0 kcal/mol) on H1R. Conclusion: In addition to antiallergic activity, molecular predications on the probable biological activities of the ginger compounds show that they can have a variety of medicinal applications including immunomodulatory and anticancer activities.

2023-06-12T00:00:00Z